About the job

Role introduction

PanKRAS represents one of the most exciting growth opportunities within AstraZeneca’s GI Oncology portfolio and is expected to play a pivotal role in our ambition to lead in Pancreatic, Colorectal, and Lung cancer. As Senior Director, Global Commercial, panKRAS, you will lead the global commercial strategy for AstraZeneca’s panKRAS asset, a clinical stage, oral, multi-target KRAS inhibitor, with the potential to transform outcomes for patients across multiple tumor settings where KRAS is considered to be a relevant clinical target.

Given the asset’s earlier stage of development, you will shape its commercial potential from the outset by providing strategic and commercial input to development priorities, evidence generation and key investment decisions. You will translate patient, customer, market and competitive insights into clear choices on target indications, patient populations, target product profile, differentiation and sequencing, while building the foundation for future launch excellence and leading commercial preparation for the panKRAS lead indication.

Job description

The Senior Director, Global Commercial, panKRAS will be part of the Global IO Commercial Franchise Team and will set and implement the global commercial strategy for this priority asset. Reflecting the asset’s earlier stage of development, the role will provide proactive commercial and strategic input to development priorities and decisions, working closely with Clinical Development, Global Medical Affairs, Regulatory Affairs, Diagnostics, Pricing and Market Access, Global Analytics & Insights, Digital, Corporate Affairs, regional and country teams, and other partners. The role will ensure that patient, customer, market and competitive insights inform indication prioritisation, target product profile, evidence-generation strategy, investment choices and the pathway to launch.

The role is accountable for creating a differentiated strategy and positioning, generating deep customer and market insights, supporting and informing development priorities and investment decisions for the clinical and evidence programme, delivering market-shaping programmes to maximise patient and business impact, and conducting commercial planning and preparations through to launch and beyond. It also represents Global Commercial perspectives in relevant cross-functional team and governance forums, ensuring development choices are grounded in future patient, customer and market needs.

Typical accountabilities | Job responsibilities

1. Global brand strategy and leadership

·     Set and communicate a clear, differentiated and long-term global brand strategy for our panKRAS asset, aligned with the GI tumour strategy and broader Oncology priorities.

·     Lead annual strategic and operational planning, including positioning, segmentation, customer strategy, value proposition, target market selection and lifecycle priorities.

·     Generate deep customer, patient, market and competitive insights and translate them into choices that address unmet need and maximise value.

·     Provide proactive commercial and strategic input to development priorities and decisions, including indication and patient-segment prioritisation, target product profile, evidence-generation needs, clinical development trade-offs and key investment choices.

·     Develop future-focused revenue forecasts and business cases informed by robust insights and sound commercial judgement.

·     Represent Global Commercial in relevant Global Product Team, development and investment decision forums, providing commercially rigorous input to evidence generation, clinical development strategy, stage-gate decisions and Phase III investment choices.

2. Launch excellence and market shaping

·     Lead global launch strategy, launch readiness and execution for panKRAS across priority markets, with clear milestones, decision points and performance measures.

·     Engage regional and country teams early, incorporate market feedback and establish mechanisms to share learning and accelerate adoption of best practice.

·     Lead agency and vendor relationships, ensuring quality, pace, compliance, value and effective use of resources.

3. Business, budget and performance management

·     Own and manage relevant global brand budgets, forecasts and resource allocation to target, with clear prioritisation and financial discipline.

·     Define a focused performance framework and use leading and lagging measures to identify gaps, risks and opportunities.

·     Provide high-quality brand and business updates to senior leadership, generating clear decisions and follow-through.

·     Proactively identify and manage strategic, operational, regulatory and reputational risks, ensuring activities comply with policy, legal, regulatory and industry requirements.

Education, qualifications, skills and experience

Essential:

·    Relevant experience in pharmaceutical development and commercialisation, with strong oncology commercial experience.

·    Proven pre-launch and launch excellence capability, including creation and execution of global brand strategies and campaigns.

·    Strong strategic marketing, customer insight, forecasting, market research, competitive analysis, and business-case skills.

·    Strong clinical and scientific acumen, with the ability to translate complex evidence into clear commercial choices.

·    Demonstrated success leading cross-functional teams in a global matrix and influencing laterally and vertically.

·    Strong business and financial acumen, including budget and agency management.

·    Exceptional written, verbal and presentation skills, with the ability to communicate clearly to senior leaders and diverse markets.

Enterprise mindset, high ethical standards, personal integrity, urgency, and the ability to deliver with a high degree of autonomy.

Desirable:

·    GI Oncology, pancreatic or colorectal cancer, or biomarker-driven therapy experience.

·    Advanced degree in business, science or related field; MBA preferred.

·    Sales, customer-facing, or market access experience.

·    Formal people-management experience.

Experience supporting late-stage development, Phase III investment decisions, or lifecycle strategy.

Compensation and Benefits

AstraZeneca is committed to providing competitive, equitable and transparent compensation. The annual base pay for this position ranges from $231,988.80 - $347,983.20 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).

Date Posted

06-Oct-2026

Closing Date

29-Oct-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.