Postdoctoral Research Fellow - Biochemistry & Molecular Biology

About the job

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

Responsibilities

We are seeking a highly motivated Research Fellow with a strong background in human stem cell biology, developmental biology, neuroscience, cancer biology, bioengineering, or a related field. Candidates with hands-on experience in human induced pluripotent stem cell (hiPSC) culture, directed differentiation, 3D organoid models, or microfluidic cell and tissue culture systems are particularly encouraged to apply.

The fellow will contribute to the development of advanced human-relevant experimental platforms, including brain organoids, brain tumor organoids, patient-derived tumor organoids, Alzheimer’s disease (AD) hiPSC-derived neural models and brain organoids, vascularized brain organoids, blood-brain barrier (BBB) models and assembloids, and microfluidic organ-on-chip and brain-organoid-on-chip systems. Research may include generation of patient-specific hiPSC models from primary patient cells, differentiation into neural and neurovascular cell types, development of multicellular 3D tissue models, and integration of neural, vascular, immune, and tumor components within microfluidic chip-based platforms to model the brain microenvironment, neurovascular interface, brain tumors, and neurodegenerative disease.

A major goal is to use these advanced human model systems for brain tumor biology, Alzheimer’s disease and neurodegenerative disease modeling, therapeutic discovery, drug delivery, BBB penetration studies, high-content and functional drug screening, and cell-based therapeutic development. The fellow may develop patient-specific AD hiPSC-derived neurons, glial cells, neurovascular models, and brain organoids to investigate disease mechanisms and evaluate candidate therapeutic strategies.

The fellow will also have opportunities to explore stem cell-based and engineered cell therapies, including evaluation of cell survival, differentiation, migration, functional integration, and therapeutic activity in advanced organoid and organ-on-chip models.

The fellow will work collaboratively with investigators in chemical biology, medicinal chemistry, pharmacology, cancer biology, neuroscience, neurodegenerative disease, cell therapy, regenerative medicine, bioengineering, genomics, and computational biology to develop innovative therapeutic, drug-screening, and disease-modeling technologies.

Preferred experience includes one or more of the following: hiPSC/hESC culture and differentiation; patient-derived hiPSC disease models; Alzheimer’s disease or other neurodegenerative disease iPSC models; brain tumor organoids or patient-derived tumor organoids; stem cell-derived brain organoids; organoid and assembloid engineering; microfluidics, lab-on-a-chip, organ-on-chip, or tissue-on-chip technologies; BBB or neurovascular models; cell therapy or regenerative medicine; CRISPR/Cas9 genome editing; advanced microscopy and quantitative imaging; transcriptomic or single-cell analyses; and pharmacological, high-throughput, or high-content screening.

Prior expertise in chemical biology, pharmacology, or cell therapy is desirable but not required. We are particularly interested in candidates with strong expertise in stem cell biology, brain organoids, brain tumor organoids, neurodegenerative disease modeling, or microfluidic bioengineering who are enthusiastic about applying these technologies to translational therapeutic development through multidisciplinary collaborations.

Qualifications

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.

Exemption Status

Exempt

Compensation Detail

$67,282.95 - $78,711.152 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Monday - Friday

Weekend Schedule

As needed

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'.  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Kara Schott